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Total Synthesis of Hopeahainol A and Hopeanol |
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| Authors: | K. C. Nicolaou Prof. Dr. T. Robert Wu Dr. Qiang Kang Dr. David Y.‐K. Chen Dr. |
| Affiliation: | 1. Chemical Synthesis Laboratory & Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, 03‐08, Singapore 138667 (Singapore), Fax: (+1)?858‐784‐2469;2. The Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037 (USA);3. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA) |
| Abstract: | Similar, but different : Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A ( 1 ) and hopeanol ( 2 ) exhibit important but differing biological properties (see structures). Their first total synthesis has now been achieved through a series of novel cascade reactions and skeletal rearrangements.  |
| Keywords: | cascade reactions natural products polyphenols total synthesis |