Life and Medical Sciences, Prog. Unit Chemical Biology and Medicinal Chemistry, University of Bonn c/o Kekulé‐Institute for Organic Chemistry and Biochemistry, Gerhard‐Domagk‐Strasse 1, 53121 Bonn (Germany), Fax: (49)?228‐734809
Abstract:
Taking a strand : Aptamers are small single‐stranded oligonucleotides that fold into a well‐defined 3D structure and interact with high affinity and specificity with their target molecules, thereby inhibiting their biological functions. Aptamers can be synthesized by either chemical and/or enzymatic procedures and can thus be considered as both chemical and biological substances. The current status and new developments in this area are described.
