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A Phosphine‐Mediated Conversion of Azides into Diazo Compounds |
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| Authors: | Eddie L. Myers Dr. Ronald T. Raines Prof. |
| Affiliation: | 1. Department of Biochemistry, University of Wisconsin‐Madison, 433 Babcock Drive, Madison, WI 53706 (USA), Fax: (+1)?1‐608‐890‐2583 http://www2.biochem.wisc.edu/raines;2. Department of Chemistry, University of Wisconsin‐Madison, 1101 University Avenue, Madison, WI 53706 (USA) |
| Abstract: | N2 the mild : Diazo compounds are extremely versatile intermediates for synthetic organic chemistry, but their synthesis can be challenging in the presence of delicate functional groups. The Staudinger ligation has inspired a mild method for the conversion of a broad range of azides into their diazo compound derivatives through an acyl triazene intermediate.  |
| Keywords: | azides heterocycles phosphines Staudinger reaction synthetic methods |