Activation of Hemiaminal Ethers by Chiral Brønsted Acids for Facile Access to Enantioselective Two‐Carbon Homologation Using Enecarbamates期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Activation of Hemiaminal Ethers by Chiral Brønsted Acids for Facile Access to Enantioselective Two‐Carbon Homologation Using Enecarbamates

Authors:	Masahiro Terada Prof. Dr. Kyoko Machioka Keiichi Sorimachi

Affiliation:	Department of Chemistry, Graduate School of Scienece, Tohoku University, Aramaki, Aoba‐ku, Sendai 980‐8578 (Japan), Fax: (+81)?22‐795‐6602, http://hanyu.chem.tohoku.ac.jp/～web/lab/index2.html

Abstract:	An enriching experience : Chiral phosphoric acids have been used to catalyze the title transformation for aromatic and aliphatic hemiaminal ethers. The process affords the corresponding products in good to high enantioselectivity (see scheme; Boc=tert‐butoxycarbonyl, G=aromatic group). The method enables facile access to highly enantioenriched 1,3‐diamine derivatives.

Keywords:	asymmetric catalysis Brø nsted acids hemiaminal ethers homologation organocatalysis