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Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of the HIJK Rings of Gymnocin A
Authors:Aaron R Van Dyke  Timothy F Jamison Prof
Institution:Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Rm 18‐492 (USA), Fax: 1‐617‐324‐0253
Abstract:Extension ladder : The successful application of epoxide‐opening strategies towards the synthesis of ladder‐type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn=benzyl).
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Keywords:cascade reactions  metathesis  natural products  polyethers  template synthesis
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