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Complete Chiral Resolution Using Additive‐Induced Crystal Size Bifurcation During Grinding |
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| Authors: | Wim L. Noorduin Pim van der Asdonk Hugo Meekes Dr. Willem J. P. van Enckevort Dr. Bernard Kaptein Dr. Michel Leeman Richard M. Kellogg Prof. Dr. Elias Vlieg Prof. Dr. |
| Affiliation: | 1. IMM Solid State Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands), Fax: (+31)?24‐365‐3067;2. Innovative Synthesis & Catalysis, DSM Pharmaceutical Products, PO Box 18, 6160 MD Geleen (The Netherlands);3. Syncom BV, Kadijk 3, 9747 AT Groningen (The Netherlands) |
| Abstract: | Grinding them down: By using a tailor‐made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R=o‐tolyl.  |
| Keywords: | amino acids chiral resolution chirality crystal engineering grinding |