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Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks |
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| Authors: | Dongbing Zhao Wenhai Wang Fei Yang Jingbo Lan Prof?Dr Li Yang Ge Gao Prof?Dr Jingsong You Prof?Dr |
| Institution: | Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (PR China), Fax: (+86)?28‐8541‐2203 |
| Abstract: | A window of opportunity : A general copper‐catalyzed C? H bond‐activation path allows arylation of heterocycles with a wide range of aryl bromides (see scheme). The reaction shows excellent regioselectivity and exhibits good functional group tolerance. The 8‐aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.  |
| Keywords: | arylation copper fluorescence fluorophores heterocycles |