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Cation–π Interactions at the Active Site of Factor Xa: Dramatic Enhancement upon Stepwise N‐Alkylation of Ammonium Ions |
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| Authors: | Laura?M Salonen Christoph Bucher David?W Banner Dr Wolfgang Haap Dr Jean‐Luc Mary Jörg Benz Dr Olivier Kuster Paul Seiler W?Bernd Schweizer Dr François Diederich Prof?Dr |
| Institution: | 1. Laboratorium für Organische Chemie, ETH Zürich, H?nggerberg, HCI, 8093 Zürich (Switzerland), Fax: (+41)?44‐632‐1109;2. Pharma Division, Pr?klinische Forschung, F. Hoffmann‐La Roche AG, 4070 Basel (Switzerland) |
| Abstract: | |
| Keywords: | dipolar interactions enzymes inhibitors molecular recognition pi interactions |