1. Amgen, Inc. 1120 Veterans Blvd., South San Francisco, CA 94080 (USA);2. Department of Chemistry, Stanford University, Stanford, CA 94305‐5080 (USA), Fax: (+1)?650‐725‐0259
Abstract:
Weaving an intricate web : A stereoselective synthesis of (?)‐agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh‐catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.
