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A Mechanism of Efficient G6PD Inhibition by a Molecular Clip |
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| Authors: | Michael Kirsch Priv‐Doz Peter Talbiersky Dipl‐Chem Jolanta Polkowska Dr Frank Bastkowski Dr Torsten Schaller Dr Herbert de Groot Prof Dr Dr Frank‐Gerrit Klärner Prof Dr Thomas Schrader Prof Dr |
| Institution: | 1. Institut für Physiologische Chemie, Iniversit?tsklinikum Essen, Hufelandstrasse 55, 45122 Essen (Germany);2. Institut für Organische Chemie, Universit?t Duisburg‐Essen, Universit?tsstrasse 5, 45117 Essen (Germany), Fax: (+49)?201‐183‐4252 |
| Abstract: | Triple duty : A synthetic molecular clip traps nicotinamide adenine dinucleotide phosphate (NADP+; see picture) as well as occupying both the cofactor‐ and the substrate‐binding site in glucose‐6‐phosphate (G6P) dehydrogenase. This combination of two inhibition mechanisms makes the clip highly effective and selective for this enzyme over other dehydrogenases.  |
| Keywords: | cofactors enzymes host– guest systems inhibitors molecular clips |