1. Institut für Organische Chemie, Universit?t des Saarlandes, Postfach 151150, 66041 Saarbrücken (Germany), Fax: (+49)?681‐302‐2409 http://www.uni‐saarland.de/fak8/kazmaier;2. Institut für Pharmazeutische Biotechnologie, Universit?t des Saarlandes, Postfach 151150, 66041 Saarbrücken (Germany), Fax: (+49)?681‐302‐70202 http://www.myxo.uni‐saarland.de
Abstract:
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.
