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Coupling Microdroplet Microreactors with Mass Spectrometry: Reading the Contents of Single Droplets Online |
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| Authors: | Luis M. Fidalgo Graeme Whyte Dr. Brandon T. Ruotolo Dr. Justin L. P. Benesch Dr. Florian Stengel Chris Abell Prof. Carol V. Robinson Prof. Wilhelm T. S. Huck Prof. |
| Affiliation: | 1. Melville laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (United Kingdom), Fax: (+44)?1223‐334‐866;2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (United Kingdom) |
| Abstract: | Fully integrated : Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 μm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on‐chip protein evolution and chemical synthesis.  |
| Keywords: | fluorescence screening high‐throughput screening mass spectrometry microdroplets microfluidics |