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Selective Adsorption of DNA on Chiral Surfaces: Supercoiled or Relaxed Conformation |
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| Authors: | Hui Gan Dr Kangjian Tang Dr Taolei Sun Dr Michael Hirtz Yong Li Lifeng Chi Prof?Dr Stefan Butz Dr Harald Fuchs Prof?Dr |
| Institution: | 1. Physikalisches Institut, WWU Münster, Wilhelm‐Klemm‐Strasse 10, 48149 Müster (Germany), Fax: (+49)?251‐83‐33602;2. Beijing Institute of Transfusion Medicine, Beijing 100850 (China);3. Center for Nanotechnology, 48151 Münster (Germany);4. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China);5. Max‐Planck‐Institut für Molekulare Biomedizin, 48149 Müster (Germany) |
| Abstract: | The right fit : Plasmid DNA molecules show chirality‐dependent interaction with gold surfaces modified by L and D N‐isobutyrylcysteine. Relaxed DNA molecules have a stronger interaction and adsorption on the L surface, while their counterparts on the D surface maintain a supercoiled conformation, indicating a weak interaction (see picture).  |
| Keywords: | chirality conformation analysis DNA stereoselective interaction surface chirality |