Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA), Fax: (+1)?970‐491‐1801
Abstract:
CO! You had me at hello : The use of chiral biphenyl‐based phosphoramidite ligands on rhodium provides an efficient 2+2+2] cycloaddition between terminal alkyl alkynes and alkenyl isocyanates (see scheme). The cycloaddition proceeds through a CO migration pathway, and facilitates a rapid four‐step asymmetric synthesis of indolizidine (?)‐209D.
