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Continuous Separation of Racemic 3,5‐Dinitrobenzoyl‐Amino Acids in a Centrifugal Contact Separator with the Aid of Cinchona‐Based Chiral Host Compounds
Authors:Andrew J Hallett Dr  Gerard J Kwant Dr  Johannes G de Vries Prof Dr
Institution:DSM Pharmaceutical Products, Innovative Synthesis & Catalysis, P.O. Box 18, 6160 MD Geleen (The Netherlands), Fax: (+31)?46‐4767604
Abstract:Resolution through revolution : It is possible to extract 3,5‐dinitrobenzoyl‐protected amino acids enantioselectively with the aid of a table‐top centrifugal contact separator and a catalytic amount of a chiral host compound based on the Cinchona alkaloids. Enantioselectivities of up to 80 % could be reached in a single pass. This allows the development of a process for the continuous separation of racemates.
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Keywords:amino acids  host–  guest systems  liquid‐phase separation  membranes  process intensification  transport
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