Synthesis of 2,4,6‐trisubstituted naphthalenes via novel copper‐promoted tandem coupling and intramolecular cyclization |
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| Authors: | Yuguang Wang Bingchun Zhu Qin Zhu |
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| Affiliation: | 1. Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, People's Republic of China;2. Zhejiang Research Institute of Chemical Industry, Hangzhou, Zhejiang, 310023, People's Republic of China |
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| Abstract: | An unprecedented copper‐promoted tandem coupling and intramolecular cyclization reaction is disclosed. This strategy offers a simple and promising method for accessing 2,4,6‐trisubstituted naphthalenes. A reaction mechanism involving initial formation of diynes followed by a 6‐exo‐dig cyclization and subsequent rearrangement is proposed. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | intramalecular cyclization coupling tandem reaction copper catalyst naphthalenes |
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