1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86)?21‐6416‐6128;2. Department of Chemistry and Chemical Biology, The State University of New Jersey, Piscataway (USA)
Abstract:
From imines to amines through catalysis by IrI complexes of a new type of P,N ligand (see scheme): This reaction affords the corresponding optically active amines with up to 98 % ee and has also been used with perfect stereoselectivity in the asymmetric synthesis of sertraline ( 1 ), an important antidepressant chiral drug.
