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Self‐Assembly of One‐ and Two‐Dimensional Hemoprotein Systems by Polymerization through Heme–Heme Pocket Interactions |
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| Authors: | Hiroaki Kitagishi Dr. Yasuaki Kakikura Hiroyasu Yamaguchi Dr. Koji Oohora Akira Harada Prof. Dr. Takashi Hayashi Prof. Dr. |
| Affiliation: | 1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2‐1 Yamadaoka, Suita 565‐0871 (Japan), Fax: (+81)?6‐6879‐7930;2. Present address: Department of Molecular Chemistry and Biochemistry, Doshisha University, Kyotanabe, Kyoto 610‐0321 (Japan);3. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka 560‐0043 (Japan) |
| Abstract: | Supramolecular protein polymers : When a heme moiety was introduced to the surface of an apo‐cytochrome b562(H63C) mutant, supramolecular polymers formed through noncovalent heme–heme pocket interactions. The incorporation of a heme triad as a pivot molecule in the protein polymer further led to a two‐dimensional protein network structure, which was visualized by tapping‐mode atomic force microscopy (see picture).  |
| Keywords: | cytochrome b562 heme proteins protein modifications self‐assembly supramolecular chemistry |