1. The Institute for Chemical Physics and School of Science, Beijing Institute of Technology, Beijing 100081 (China);2. ?rebro Life Science Center, School of Science and Technology, ?rebro University, 701 82 ?rebro (Sweden)
Abstract:
Cutting ties : Strand scission and base release in hydroxy‐radical adducts of 3′‐uridine monophosphate (UMP) have been explored by using density functional theory. The presence of the ribose 2′‐OH group and the resultant formation of low‐barrier hydrogen bonds with oxygen atoms of the 3′‐phosphate linkage are highly important for hydrogen transfer and the subsequent bond‐breakage reactions (see picture).
