1. Leibniz Institute for Molecular Pharmacology (FMP), Robert‐R?ssle‐Strasse 10, 13125 Berlin (Germany), Fax: (+49)?30‐9406‐2981;2. Institute for Chemistry and Biochemistry, Free University Berlin, Takustrasse 3, 14195 Berlin (Germany)
Abstract:
Metal‐free triazole turns : 1,5‐Disubstituted peptidyl triazoles are obtained regioselectively from the 1,3‐dipolar cycloaddition of peptidyl phosphoranes and azides. Peptide turns are thus formed that contain a conformationally locked cis peptide bond. Being regioselective and free of heavy metals, this reaction may find broad application in chemical biology and medicinal chemistry.
