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Efficient Catalytic Promiscuity for Chemically Distinct Reactions |
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| Authors: | Ann C. Babtie Subhajit Bandyopadhyay Dr. Luis F. Olguin Dr. Florian Hollfelder Dr. |
| Affiliation: | 1. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA (UK), Fax: (+44)?1223‐766‐002, http://www.bioc.cam.ac.uk/～fh111;2. Current address: Indian Institute of Science Education & Research (IISER), HC—Sector III, Salt Lake City, Kolkata 700106 (India) |
| Abstract: | High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants Ktx) suggest that the trade‐off between high activity and tight specificity can be substantially relaxed.  |
| Keywords: | catalytic promiscuity enzyme catalysis hydrolases phosphatases sulfatases |