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Novel types of boronated chlorin e6 conjugates via ‘click chemistry’ |
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| Authors: | Vladimir I. Bregadze Andrey A. Semioshkin Julia N. Las'kova Maria Ya. Berzina Irina A. Lobanova Igor B. Sivaev Mikhail A. Grin Rustam A. Titeev Dmitry I. Brittal Olga V. Ulybina Anastasija V. Chestnova Anastasija A. Ignatova Alexey V. Feofanov Andrey F. Mironov |
| Affiliation: | 1. A.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Str. 28, 119991, Moscow, Russia;2. M.V.Lomonosov Moscow State Academy of Fine Chemical Technology, Vernadskii Prosp. 86, 119571, Moscow, Russia;3. Shemyakin‐Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho‐Maklay Str., 16/10, 117997 Moscow, Russia;4. Biological Faculty, Lomonosov Moscow State University, Vorobyevi Gori 1, Moscow, 119992, Russia |
| Abstract: | Conjugates of chlorin e6 with closo‐dodecaborate and cobalt bis(dicarbollide) anions were synthesized for the first time in high yields using the advanced ‘click’ methodology. In vitro study on A549 human lung adenocarcinoma cells revealed that the synthesized boronated conjugates are able to penetrate and accumulate in cancer cells, but their intracellular concentration is not sufficient for effective photodynamic and boron neutron capture therapy of cancer. Copyright © 2009 John Wiley & Sons, Ltd. |
| Keywords: | chlorin e6 boronated conjugates PDT BNCT |