Départment de Chimie Moléculaire, UMR CNRS/UJF 5250, ICMG FR 2607, 301, rue de la chimie, BP53, 38041 Grenoble cedex 9 (France), Fax: (+33)?4‐7651‐4946
Abstract:
Click–click cyclopeptides : Well‐defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)‐mediated alkyne–azide cycloaddition reactions in a stepwise or in a one‐pot approach. To illustrate this strategy, regioselective ligation of biologically relevant peptides onto a cyclopeptidic scaffold was performed.