Cytotoxic constituents from Podocarpus fasciculus |
| |
Authors: | Kuo Yu-Jen Hwang Shy-Yuan Wu Ming-Der Liao Chia-Ching Liang Yu-Han Kuo Yao-Haur Ho Hsiu-O |
| |
Institution: | National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC. |
| |
Abstract: | A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED(50)=2.57 microg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|