Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer |
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| Authors: | Wilson Andrew J Groves Kevin Jain Rishi K Park Hyung Soon Hamilton Andrew D |
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| Institution: | Department of Chemistry, P.O. Box 208107, 225 Prospect Street, Yale University, New Haven, CT 06520-8107, USA. |
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| Abstract: | Using circular dichroism, UV-vis, and trypsin proteolysis, we have shown how a metalloporphyrin dimer induces the unfolding of a protein, cytochrome c, under physiologically relevant conditions and accelerates its rate of proteolytic degradation. |
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