Promotion of one-pot Robinson annelation achieved by gradual pressure and temperature manipulation under supercritical conditions |
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| Authors: | Hajime Kawanami Yutaka Ikushima |
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| Institution: | National Institute of Advanced Industrial Science and Technology, CREST, Japan Science and Technology Cooperation (JST), 4-2-1 Nigatake, Miyagino-ku, Sendai 983-8551, Japan |
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| Abstract: | The one-pot Robinson annelation from 2-methyl-cyclohexane-1,3-dione with 3-buten-2-one can be achieved in high yield (95%) and high selectivity (95%) by pressure and temperature manipulation using supercritical carbon dioxide in the presence of MgO catalyst, whose method could be applied for various ketones to synthesize fused polycyclic compounds. |
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| Keywords: | Robinson annelation Supercritical CO2 One-pot reaction |
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