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Rapid and facile Lewis acid catalysed Boc protection of amines |
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| Authors: | G.V.M. Sharma J. Janardhan Reddy P. Sree Lakshmi Palakodety Radha Krishna |
| Affiliation: | D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | Efficient Boc protection of amines was carried out using (Boc)2O in the presence of a catalytic amount of ZrCl4 (10 mol %) in acetonitrile at room temperature. The reaction times are very short and the yields are generally high. |
| Keywords: | Amines Amino acids Carbo β-amino acids Lewis acid catalyst (Boc)2O |
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