Synthesis of a novel spiro bisphosphinamidite ligand for highly enantioselective hydrogenation |
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| Authors: | Ching Wen Lin |
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| Institution: | Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China |
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| Abstract: | A novel chiral bisphosphinamidite ligand SpiroNP has been synthesized. The rhodium complex of this ligand has been found to be highly active and enantioselective in the asymmetric hydrogenation of (Z)-2-acetamidoacrylic acid derivatives and α,β-unsaturated carboxylic acid derivatives. |
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