One-pot sequential Baylis-Hillman and Michael reactions |
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| Authors: | Wengui Wang |
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| Affiliation: | Department of Synthetic Chemistry, GlaxoSmithKline Pharmaceuticals, 709 Swedeland, PO Box 1539, King of Prussia, PA 19406, USA |
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| Abstract: | A new one-pot procedure for the sequential Baylis-Hillman and Michael reactions has been developed to construct two carbon-carbon bonds with three components. This procedure has been applied to combine a variety of aromatic aldehydes, β-unsubstituted acrylates and activated methide nucleophiles to generate highly diversified and functionalized organic compounds. |
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| Keywords: | Baylis-Hillman Michael Sequential One-pot DBU Multi-component |
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