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Lissoclibadin 1, a novel trimeric sulfur-bridged dopamine derivative, from the tropical ascidian Lissoclinum cf. badium |
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| Authors: | Hongwei Liu Teruaki Nishikawa Kazuo Tachibana Hiroshi Nagai Michio Namikoshi |
| Affiliation: | a Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan b Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, North Sulawesi, Indonesia c The Nagoya University Museum, Chikusa-ku, Nagoya 464-8601, Japan d School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan e Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan |
| Abstract: | A novel tribenzotetrathiepin alkaloid, named lissoclibadin 1 (1), has been isolated from the ascidian Lissoclinum sp. (cf. L. badium Monniot and Monniot, 1996). The gross structure was assigned on the basis of the spectral data, and one of two possible isomers was selected by the computational modeling study. Lissoclibadin 1 inhibited the growth of the marine bacterium Ruegeria atlantica (15.2 mm at 20 μg/disk). |
| Keywords: | Tunicate Lissoclinum sp. Polysulfur compound Structure assignment |
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