Identification of new catalysts for the asymmetric reduction of imines into chiral amines with polymethylhydrosiloxane using high-throughput screening |
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Authors: | Tania Ireland,Franç ois Fontanet,Guen-Gnanh Tchao |
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Affiliation: | Rhodia, Lyon Research Center, Catalysis Department, 69 192 St-Fons, France |
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Abstract: | The use of high-throughput techniques allowed the rapid identification of new catalysts for the enantioselective reduction of imines using polymethylhydrosiloxane (PMHS) as a reducing agent. By a simple modification of the chiral ligand structure that came out of the screening, the enantioselectivity of the reduction was increased from 40% ee to 60% ee. |
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Keywords: | Asymmetric imine reduction PMHS High-throughput screening |
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