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Structure and catalytic activity of some soluble polyethylene glycol-peptide conjugates |
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| Authors: | David R. Kelly Tam T.T. Bui Alex F. Drake |
| Affiliation: | a Department of Chemistry, Cardiff University, PO Box 912, Cardiff, Wales CF10 3TB, UK b Department of Pharmacy, Franklin Wilkins Building, Kings' College, London SE1 9NN, UK c Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK |
| Abstract: | Soluble catalysts for the Juliá-Colonna asymmetric epoxidation reaction have been constructed in three different ways, using NH2-PEG-OMe as the support system: suitable solvents have been identified and it is shown that the degree of helicity of the conjugates correlates with the extent of conversion and (to a lesser extent) the enantioselectivity of epoxidation. |
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