New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides |
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| Authors: | Thomas Colin,Laetitia Gaultier,Laurence Grimaud,Laurent Gatay,Valé rie Michaut |
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| Affiliation: | Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75015 Paris, France |
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| Abstract: | Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane. |
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| Keywords: | Trifluoromethyl group Pyruvamide Isocyanide Enamines |
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