Total synthesis of nothapodytine B and (±)-mappicine |
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| Authors: | Subhash P Chavan Rasapalli Sivappa |
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| Institution: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, Maharashtra, India |
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| Abstract: | A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B (2, mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assembly of a pyridone D ring precursor with the necessary functionalities. Nothapodytine B is converted into mappicine 3 by NaBH4 reduction. |
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| Keywords: | Total synthesis Nothapodytine B Mappicine Johnson orthoester rearrangement Pyridone |
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