A new total synthesis of (±)-oestrone |
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Authors: | Gerald Pattenden L Krishnakanth Reddy Affo Walter |
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Institution: | School of Chemistry, The University of Nottingham, Nottingham NG7 2RD, UK |
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Abstract: | A conceptually new total synthesis of oestrone, based on a novel cascade of radical cyclisations from the iodo aryl vinylcyclopropane 2, via 10, 15, 16 and 17, leading to the intermediate trans,anti,trans-oestradiol derivative 11 in one step, is described. Oxidation of 11, followed by demethylation of the resulting aryl methyl ether 18 then gives (±)-oestrone 1. |
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