Stereocontrolled synthesis of a potent antimalarial alkaloid, (+)-febrifugine |
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| Authors: | Miho Katoh |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan |
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| Abstract: | A novel and stereocontrolled synthetic path to a potential antimalarial piperidine alkaloid, (+)-febrifugine, was established by employing the reductive deamination and simultaneous recyclization of a proline derivative with samarium diiodide, as a key step. |
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| Keywords: | Febrifugine Isofebrifugine Tandem Horner-Emmons-Michael reaction Samarium diiodide Antimalarial activity |
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