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Boron tribromide mediated debenzylation of benzylamino and benzyloxy groups
Authors:Ekaterina Paliakov
Affiliation:Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
Abstract:The treatment of 2(or 4)-benzylamino substituted quinolines, 9-benzylaminoacridine, 2-benzylaminopyridine, a 4-benzyloxyquinoline, and an N-benzyloxyamidine with BBr3 yields the corresponding amino or hydroxy substituted compounds. The scope and limitations of this novel reaction are discussed.
Keywords:Boron tribromide   Debenzylation   Benzylamino   Benzyloxy
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