|
|||||
|
|
A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles |
|
| Authors: | Steve Price Richard Bull Sophie Gardan David Neighbour Iwan JP de Esch |
| Institution: | a Argenta Discovery Ltd, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK b De Novo Pharmaceuticals Ltd, Compass House, Vision Park, Histon, Cambridge CB4 9ZR, UK |
| Abstract: | A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing a sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. |
| Keywords: | Electrophilic sulfinylation Imidazole Trianion Guanidine Sulfonamides |
| 本文献已被 ScienceDirect 等数据库收录！ | |