Stereoselective intramolecular hetero Diels-Alder reactions of 1-oxa-1,3-butadienes: a novel approach for the synthesis of complex annulated uracils |
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| Authors: | Ipsita Devi |
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| Institution: | Medicinal Chemistry Division, Regional Research Laboratory, Jorhat 785006, Assam, India |
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| Abstract: | The intramolecular hetero Diels-Alder reactions of 1-oxa-1,3-butadienes 4, obtained from salicylaldehyde 1 via O-allylation followed by Knoevenagel condensation with barbituric acids 3 in the presence of hydrochloric acid as catalyst, affords the tetracyclic uracil derivatives 5 and 6 in a stereoselective manner and high overall yields. |
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| Keywords: | Intramolecular hetero Diels-Alder reaction Uracil 1-Oxa-1 3-butadiene Stereoselective synthesis |
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