A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)-tetraenoic acid, an endogenous vasoconstrictor |
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| Authors: | SG Jagadeesh Alberto Nasjletti |
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| Institution: | a Department of Biochemistry, University of Texas, Southwestern Medical Center, Dallas, TX 75390-9038, USA
b Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA |
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| Abstract: | 12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynylation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries. |
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