A novel procedure for the synthesis of multifunctional ketones through the Fukuyama coupling reaction employing dialkylzincs |
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| Authors: | Yoshikazu Mori |
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| Institution: | a Process Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan
b Export and Import Group, Purchasing Department, Logistics Division, Tanabe Seiyaku Co., Ltd, 3-2-10, Dosho-Machi, Chuo-Ku, Osaka 541-8505, Japan |
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| Abstract: | Treatment of thiol esters 1 with dialkylzincs 2 in the presence of zinc bromide, that was in situ prepared from zinc dust and bromine, provided various functionalized ketones 3 in high yields. The reaction mechanism, which may shift the Schlenk equilibrium from dialkylzincs 2 to reactive alkylzinc bromide 5, was postulated to account for the facile coupling reaction. |
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