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Two successive one-pot reactions leading to the expeditious synthesis of (−)-centrolobine |
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| Authors: | Lucie Boulard Janine Cossy Xavier Franck |
| Affiliation: | a Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France b Laboratoire de Pharmacognosie associé au CNRS (BioCIS), Faculté de Pharmacie, Université Paris-Sud, rue Jean-Baptiste Clément, 92296 Châtenay Malabry, France |
| Abstract: | A very short and efficient synthesis of (−)-centrolobine has been achieved by using two successive one-pot reactions. The first sequence involves a cross-metathesis reaction/hydrogenation/lactonization and the second sequence is a Grignard addition/reduction. |
| Keywords: | Centrolobine One-pot reaction Cross-metathesis Allyltitanation |
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