Novel Biginelli-like three-component cyclocondensation reaction: efficient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones |
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| Authors: | Zong-Ting Wang Li-Wen Xu Chun-Gu Xia |
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| Institution: | a State key laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China
b Department of Applications Chemistry, University of Petroleum (East China), Dongying, Shandong 257062, PR China |
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| Abstract: | Iron (III) catalyzed the three-component Biginelli-like cyclocondensation reaction efficiently in acetonitrile to afford the corresponding 5-unsubstituted 3,4-dihydropyrimidin-2-(1H)-ones in high yields. The first Biginelli-like reactions of urea, aldehydes and ketones were furnished important new 3,4-dihydropyrimidin-2-(1H)-ones derivatives suitable for further study. |
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| Keywords: | Three component Biginelli-like reaction Cyclocondensation One pot Iron |
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