Efficient synthesis of extended guanine analogues designed for recognition of an A·T inverted base pair in triple helix based-strategy |
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| Authors: | Nathalie Van Craynest Corinne Peyron |
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| Institution: | Laboratoire de Chimie Bioorganique UMR-CNRS 6001, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France |
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| Abstract: | We report herein an efficient synthesis of new nucleosides N1, N2, and N3 as extended guanine analogues, derived from aminobenzimidazole and thymine or 5-substituted uracil. These nucleosides were devised for the recognition of an A·T inverted base pair by three hydrogen bonds, in triple helix-based technology. |
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| Keywords: | Extended nucleosides Triple helix Molecular recognition |
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