Asymmetric synthesis of (R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid as a key intermediate for a neurodegenerative disease agent |
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| Authors: | Tomomi Ikemoto Mitsuhisa Yamano Tatsuya Ito Yukio Mizuno Kiminori Tomimatsu |
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| Affiliation: | Chemical Development Laboratories, Takeda Chemical Industries, Ltd., 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan |
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| Abstract: | An asymmetric synthesis of (R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid 2 as a key intermediate for a neurodegenerative disease agent 1 has been developed. A key reaction was an asymmetric hydrogenation of hindered acrylic acid 13 catalyzed by the Rh-JOSIPHOS system in the presence of a base to afford a chiral acid up to 93% ee. |
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| Keywords: | Asymmetric reduction Rh-JOSIPHOS catalyst |
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