Thioglycosylated cationic porphyrins--convenient synthesis and photodynamic activity in vitro |
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Authors: | Sajida Ahmed |
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Institution: | Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull, East Yorkshire, HU6 7RX, UK |
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Abstract: | A convenient and flexible synthesis of meso-tetraaryl porphyrins substituted with three thioglycosyl units, and also bearing one pyridyl substituent is reported. Quaternisation of the pyridine nitrogen with alkyl iodides gives access to a range of water soluble glycosyl cationic porphyrins. Screening for photodynamic activity against human colorectal adenocarcinoma cells (HT-29) indicates that all the glycosyl cationic porphyrins made in this way are active photosensitisers, but direct comparison with a cationic porphyrin bearing no sugar residues indicates an important role for these groups in reducing generalised `dark' toxicity. |
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Keywords: | Porphyrins Photobiology |
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