首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Thioglycosylated cationic porphyrins--convenient synthesis and photodynamic activity in vitro
Authors:Sajida Ahmed
Institution:Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull, East Yorkshire, HU6 7RX, UK
Abstract:A convenient and flexible synthesis of meso-tetraaryl porphyrins substituted with three thioglycosyl units, and also bearing one pyridyl substituent is reported. Quaternisation of the pyridine nitrogen with alkyl iodides gives access to a range of water soluble glycosyl cationic porphyrins. Screening for photodynamic activity against human colorectal adenocarcinoma cells (HT-29) indicates that all the glycosyl cationic porphyrins made in this way are active photosensitisers, but direct comparison with a cationic porphyrin bearing no sugar residues indicates an important role for these groups in reducing generalised `dark' toxicity.
Keywords:Porphyrins  Photobiology
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号