Palladium-catalyzed intramolecular α-arylation of sulfoximines |
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| Authors: | Carsten Bolm Hiroaki Okamura Marinella Verrucci |
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| Affiliation: | Institut für Organische Chemie der RWTH Aachen, Professor-Pirlet-Straße 1, D-52056 Aachen, Germany |
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| Abstract: | The palladium-catalyzed cyclization of N-(2-bromobenzyl)- and N-(2-bromobenzoyl)-sulfoximines affords six-membered heterocycles in moderate to good yield. In both cases, the α-arylations of the sulfoximine methyl groups are catalyzed by combination of Pd(OAc)2 and rac-BINAP in the presence of a base such as Cs2CO3 or K2CO3. |
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| Keywords: | Arylation Catalysis Cyclization Palladium Sulfoximine |
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