Uncatalysed coupling of an activated aryl chloride with aryllithium and aryl Grignard reagents |
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Authors: | Demet Astley |
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Affiliation: | Faculty of Science, Department of Chemistry, Ege University, Bornova, Izmir, Turkey 35100 |
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Abstract: | Substitution of the chloro group in 2-(2-chlorophenyl)-4,4-dimethyl-2-oxazoline to afford biaryls occurs upon reaction with either aryllithium reagents or aryl Grignard reagents. The reactions with Grignard reagents occur under similar conditions to a previously reported manganese-catalysed procedure. The reactions with lithium reagents, whilst not always affording greater yields of product than the Grignard reagents, involve much shorter reaction times and afford yields, which are comparable with those obtained from the corresponding fluoro derivative. |
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Keywords: | Nucleophilic aromatic substitution Aryl chloride Aryllithium Aryl Grignard reagent Coupling |
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