General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines |
| |
| Authors: | Zhijian Zhao |
| |
| Institution: | Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA |
| |
| Abstract: | Functionalized quinoxalines and heterocyclic pyrazines are expediently prepared in excellent yields (69-99%) from common 1,2-diketone intermediates under microwave irradiation. In addition to being general for a variety of aryl/heteroaryl 1,2-diamines and 1,2-diketones, this protocol suppresses the formation of polymeric species, characteristic of traditional thermal conditions. |
| |
| Keywords: | Microwave Quinoxaline Pyrazine |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
