An enantioselective synthesis of phomopsolide D |
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Authors: | Miaosheng Li |
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Affiliation: | Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA |
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Abstract: | A short enantioselective route to the highly functionalized α,β-unsaturated δ-lactone natural product phomopsolide D and three of its stereoisomers, has been accomplished. All of the carbon atoms of phomopsolide D come from tiglic acid and 2-furyl-1-penta-1′,3′-dienylketone (furan plus hexadienal). This approach derives its asymmetry from the sequential use of two catalytic asymmetric reactions; these being a Sharpless dihydroxylation reaction and a Noyori furylketone reduction. The resulting furfuryl alcohols were stereoselectively transformed into α,β-unsaturated δ-lactones via a short highly diastereoselective oxidation and reduction sequence. |
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